Spasticity in Spinal Cord Disorders

John W. McDonald and Cristina L. Sadowsky

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI:

Series: Contemporary Neurology Series

Spasticity in Spinal Cord Disorders

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Care of patients with spinal cord dysfunction caused by trauma, multiple sclerosis, transverse myelitis, infections, and other acquired and degenerative diseases is common in the practice of neurology. The clinical presentations of all these disorders are dominated by spasticity, which is a major cause of pain and disability. The therapies available to the clinician to manage spasticity have expanded substantially over the past half-century, particularly in the past two decades. In this chapter, we provide an overview of the rationale and recommendations for current treatment options, based on a balance of anatomy, physiology, pathophysiology, pharmacology, clinical practice guidelines, as well as stem cell and regeneration research.

Chapter.  10382 words.  Illustrated.

Subjects: Neurology

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