Chapter

Neuromuscular Disease

Chad Heatwole and Richard Moxley III

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI: http://dx.doi.org/10.1093/med/9780195146837.003.0502

Series: Contemporary Neurology Series

Neuromuscular Disease

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Neuromuscular disorders encompass a broad spectrum of disease processes and anatomical dysfunction. In the past, pharmacological therapies of neuromuscular diseases have focused on providing symptomatic relief. In the last several decades, neuromuscular pharmacology has broadened its aims to include both symptom-altering agents and disease modifiers. The labors of neuromuscular research have provided clinicians with multiple classifications of pharmacologic therapy to address the individual needs of the neuromuscular patient. Neuromuscular disease can be divided into anatomical subgroups. These groups include diseases of the: muscle, neuromuscular junction, peripheral nerve, plexus, nerve root, and anterior horn cell. These subgroups represent a myriad of neuromuscular diseases. The goal of this chapter is not to provide a detailed description of each individual neuromuscular disease, but rather to concentrate on the classification of pharmacologic therapies available to each group. This chapter will focus on representative diseases that utilize various classifications of therapy. In addition, specific mechanism of action and justification for use of each medication will be provided based on both historic and contemporary randomized clinical trials.

Chapter.  31914 words. 

Subjects: Neurology

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