Chapter

Therapies for the Neurological Complications of HIV Infection

Jeffrey A. Rumbaugh

in Principles of Drug Therapy in Neurology

Second edition

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780195146837
Published online April 2013 | e-ISBN: 9780199322961 | DOI: http://dx.doi.org/10.1093/med/9780195146837.003.0926

Series: Contemporary Neurology Series

Therapies for the Neurological Complications of HIV Infection

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Neurons are rarely infected by the human immunodeficiency virus (HIV), yet neuronal loss in patients with HIV infection is common, likely due to the effects of viral proteins and inflammatory mediators on these cells. HIV infection thereby frequently causes cognitive impairment and other neurological complications, often striking patients during the prime working years of their lives, with major personal and socioeconomic consequences. Highly active antiretroviral therapy (HAART) has reduced the incidence of severe forms of HIV associated dementia, but milder forms persist. Highly active antiretroviral therapy has also allowed patients to live longer with HIV infection, and the prevalence of HIV dementia is actually rising.1–5 Additionally, many patients are noncompliant with complicated HAART regimens or their HIV infection may become resistant to available HAART therapies. Some patients, especially in developing nations, may not have access to these drugs. Fortunately, important recent findings have advanced our understanding of the molecular mechanisms by which HIV infection causes neuronal damage, demonstrating numerous potential therapeutic targets.6

Chapter.  30881 words.  Illustrated.

Subjects: Neurology

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