Chapter

Specificity In Nerve Regeneration

Thomas M. Brushart

in Nerve Repair

Published on behalf of Oxford University Press

Published in print May 2011 | ISBN: 9780195169904
Published online September 2012 | e-ISBN: 9780199965168 | DOI: http://dx.doi.org/10.1093/med/9780195169904.003.0010
Specificity In Nerve Regeneration

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  • Sensory and Motor Systems
  • Rehabilitation Medicine

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The potential exists for regeneration specificity at several levels within the peripheral nervous system: tissue, nerve trunk, sensory/motor, topographic, and end organ. Specificity may be generated by mechanical alignment of nerve stumps, contact recognition, neurotropism, or neurotrophism. Preferential motor reinnervation (PMR) is the tendency for motor axons regenerating in mixed nerve to reinnervate motor pathways and/or muscle. PMR is more prominent in young animals and when motor axons are permitted to reinnervate muscle, and occurs in response to freshly denervated muscle nerve in young rats and to predegenerated muscle nerve in adult rats. Topographic specificity of both sensory and motor regeneration is dependent upon mechanical axon alignment.

Chapter.  12710 words.  Illustrated.

Subjects: Sensory and Motor Systems ; Rehabilitation Medicine

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