Disorders of Peripheral Nerve Hyperexcitability

Steven Herskovitz

in Peripheral Neuropathies in Clinical Practice

Published on behalf of Oxford University Press

Published in print November 2008 | ISBN: 9780195183269
Published online April 2013 | e-ISBN: 9780199322947 | DOI:


Disorders of Peripheral Nerve Hyperexcitability

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Disorders associated with excess motor unit activity may arise from the central nervous system (CNS) or the peripheral nervous system (PNS).1 In the CNS, corticospinal tract lesions result in spasticity. Extrapyramidal lesions cause disorders of muscle posture and tone. Disorders of spinal inhibitory interneurons are associated with stiff-person syndrome, tetanus, and strychnine poisoning. Table 20–1 outlines the disorders associated with hyperexcitability of the peripheral nerve axon. Various ectopic discharges arise along the course of peripheral motor or sensory axons. Their origin in peripheral nerve can be established by the following characteristics: unaffected by general anesthesia, sleep, or nerve block proximal to the lesion site, and abolished by nerve block distal to the lesion site or neuromuscular transmission blockade.

Chapter.  3647 words.  Illustrated.

Subjects: Neurology

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