Pathophysiology of Nervous System Metastases

Lisa M. Deangelis and Jerome B. Posner

in Neurologic Complications of Cancer

Second edition

Published on behalf of Oxford University Press

Published in print September 2008 | ISBN: 9780195366747
Published online April 2013 | e-ISBN: 9780199322879 | DOI:

Series: Contemporary Neurology Series

Pathophysiology of Nervous System Metastases

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Unlike primary brain tumors (e.g., glioblastoma) that cause death as a direct result of local tumor growth, most other cancers can be controlled locally; death occurs only if the tumor metastasizes. Unfortunately, as many as 60% of patients with cancer have overt or occult metastases at the time of diagnosis,1 rendering them virtually incurable. Metastases to the nervous system are a major cause of neurologic disability in patients with cancer and are often the direct cause of death. Metastases to the nervous system cause approximately one-half of the significant neurologic complications of cancer.2,3

Chapter.  19819 words.  Illustrated.

Subjects: Neurology

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