Chapter

The Dopamine D4 Receptor Gene

David A. Mrazek

in Psychiatric Pharmacogenomics

Published on behalf of © 2010 by David A. Mrazek

Published in print June 2010 | ISBN: 9780195367294
Published online June 2013 | e-ISBN: 9780199323128 | DOI: http://dx.doi.org/10.1093/med/9780195367294.003.0572
The Dopamine D4 Receptor Gene

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Chapter 17 discusses The dopamine receptor gene (DRD4), which encodes for the D4 subtype of the dopamine receptor. The D4 subtype is relatively homologous to both the D2 and D3 subtypes of the dopamine receptors. All three of these subtypes are G-protein coupled receptors that inhibit the enzyme adenylyl cyclase. The D4 subtype is located predominantly in the prefrontal cortex. The density of the D4 receptors has been reported to be greater in the brains of patients with schizophrenia, where the density of D4 receptors has been reported to be lower in the brains of patients with Parkinson disease, and it is thus a target for many drugs that have been used to treat patients with schizophrenia and Parkinson disease. Mutations in the DRD4 gene have been associated with multiple behavioral phenotypes. These include attention-deficit hyperactivity disorder (ADHD), and the personality trait of novelty seeking.

Chapter.  4120 words.  Illustrated.

Subjects: Psychiatry ; Neuroscience

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