Chapter

Neurobiology of White Matter Disorders

Christopher M. Filley

in Diffusion MRI

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780195369779
Published online September 2012 | e-ISBN: 9780199965144 | DOI: http://dx.doi.org/10.1093/med/9780195369779.003.0002
Neurobiology of White Matter Disorders

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White matter makes up approximately one-half of the brain's volume, and myelinated tracts course within and between the cerebral hemispheres to integrate gray matter structures into distributed neural networks. White matter can be directly damaged by a wide range of neuropathological insults and is involved in neurodegenerative diseases. The study of white matter has been stimulated by advances in neuroimaging such as diffusion tensor imaging (DTI) that permit more detailed analysis of normal and abnormal structure and function. Cognition and emotion, as well as many challenging clinical disorders, may be illuminated by considering the potential contribution of white matter. A prominent syndrome is white matter dementia, which affects people of all ages and features slowed processing speed. Study of white matter with DTI promises to improve understanding of a variety of clinical problems and address many neuroscientific issues.

Chapter.  9539 words.  Illustrated.

Subjects: Neuroscientific Techniques

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