Diffusion Tensor Microimaging and Its Applications

Jiangyang Zhang, Hao Huang, Manisha Aggarwal and Susumu Mori

in Diffusion MRI

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780195369779
Published online September 2012 | e-ISBN: 9780199965144 | DOI:
Diffusion Tensor Microimaging and Its Applications

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Diffusion tensor imaging (DTI) provides superior contrast for structural delineation in the brain. Two major challenges for using DTI to study small animal brains are the limitation on spatial resolution and our limited knowledge of the relationships between DTI contrast and underlying tissue microstructure. This chapter describes several practical techniques for achieving diffusion tensor microimaging (DTMI). While focusing mainly on the mouse brain, it demonstrates the usefulness and limitations of DTMI contrast in delineating brain structures, especially in the developing brains. Several applications of DTMI in studying development and maturation in the rat brain and brain connectivity in the macaque brain are also presented.

Chapter.  8965 words.  Illustrated.

Subjects: Neuroscientific Techniques

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