Chapter

Diffusion Imaging in Muscle

Gustav J. Strijkers, Maarten R. Drost and Klaas Nicolay

in Diffusion MRI

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780195369779
Published online September 2012 | e-ISBN: 9780199965144 | DOI: http://dx.doi.org/10.1093/med/9780195369779.003.0041
Diffusion Imaging in Muscle

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Non-invasive imaging techniques to evaluate muscle structure, function, and metabolism are of tremendous importance for diagnosis and characterization of various muscle pathologies. Magnetic resonance diffusion imaging provides quantitative in vivo information on skeletal muscle geometry and local muscle histopathological status. This technology can be used to study alterations in skeletal muscle tissue following development, training, disease, therapy, or surgical intervention. Magnetic resonance diffusion imaging can be applied to study the myocardial muscle architecture non destructively in whole heart ex vivo specimens. Knowledge on heart structure and function relations forms the basis for understanding cardiac adaptation and remodeling as a consequence of pathological conditions, such as acute and chronic myocardial infarction, hypertrophy, and various forms of heart failure. Although extremely challenging, in vivo diffusion imaging of the heart is expected to find more widespread use, because it provides essential structural information on myocardial architecture that cannot be obtained otherwise.

Chapter.  14890 words.  Illustrated.

Subjects: Neuroscientific Techniques

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