Chapter

Insights into Diffusion Tensor Imaging from Animal Models of White Matter Pathology

Matthew D. Budde and Sheng-Kwei Song

in Diffusion MRI

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780195369779
Published online September 2012 | e-ISBN: 9780199965144 | DOI: http://dx.doi.org/10.1093/med/9780195369779.003.0042
Insights into Diffusion Tensor Imaging from Animal Models of White Matter Pathology

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Animal models of white matter injuries and diseases have revealed how specific pathologies contribute to diffusion changes within white matter tracts of the brain and spinal cord. Studies investigating models of demyelination, trauma, and neuronal degeneration have consistently shown that the directional diffusivities (i.e., axial and radial diffusivity) derived from diffusion tensor imaging (DTI) have greater specificity and sensitivity for axonal damage and demyelination, respectively, than either anisotropy or ADC. Although applications to the human situation have been somewhat limited, the directional diffusivities show promise as biomarkers of white matter pathology.

Chapter.  7502 words.  Illustrated.

Subjects: Neuroscientific Techniques

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