Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH

Peter J. Basser

in Diffusion MRI

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780195369779
Published online September 2012 | e-ISBN: 9780199965144 | DOI:
Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH

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This chapter documents the invention and early development of diffusion tensor (DT) NMR and MRI. It recounts personal experiences with former NIH colleagues—Denis Le Bihan and James Mattiello—from the initial conception of diffusion tensor NMR, to the definition of the apparent diffusion tensor, to the design of the first experiment to measure it. Descriptions of the state of the art in characterizing anisotropic diffusion at the time suggest the significant departure that DT-NMR and DT-MRI represented. Personal recollections and observations are woven through this account of the heady early days of DT-NMR and DT-MRI.

Chapter.  6721 words. 

Subjects: Neuroscientific Techniques

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