Chapter

Neurologic Complications of Organ Transplantation

Eelco F. M. Wijdicks

in Neurologic Complications of Critical Illness

Published on behalf of © Mayo Foundation for Medical Education and Research

Published in print May 2009 | ISBN: 9780195371093
Published online April 2013 | e-ISBN: 9780199322886 | DOI: http://dx.doi.org/10.1093/med/9780195371093.003.0020

Series: Contemporary Neurology Series

Neurologic Complications of Organ Transplantation

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Organ transplantation (simple or multivisceral) has profoundly changed the spectrum of neurologic consultations in the ICU, and a bewildering new array of neurologic complications has appeared. When they appear, neurologic complications are confined largely to use of immunosuppressive drugs or to infectious complications in immunocompromised patients. Other neurologic complications, particularly peripheral nerve damage, are related to the surgical procedure and are less specific in most instances.2 Most experience is with transplantation of kidney, pancreas, liver, heart, and lung, separately or in combination. Although in a sense not strictly an organ, hematopoietic stem cell transplantation is included here. Neurologic complication from transplantation occurs in approximately 10% of patients, but the frequency may depend on motivation of transplant teams to consult a neurologist. Prospective incidence studies may not capture all the postoperative events, and to be accurate, they would require a neurologist on daily rounds. Neurologic complications may be major when they involve recurrent seizures, postoperative failure to awaken, immunosuppression neurotoxicity, or acute disabling neuromuscular disease, all of which are addressed in this chapter.

Chapter.  16531 words.  Illustrated.

Subjects: Neurology

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