Chapter

Autism Endophenotypes and Quantitative Trait Loci

Rita M . Cantor

in Autism Spectrum Disorders

Published on behalf of Oxford University Press

Published in print May 2011 | ISBN: 9780195371826
Published online September 2012 | e-ISBN: 9780199965212 | DOI: http://dx.doi.org/10.1093/med/9780195371826.003.0045
Autism Endophenotypes and Quantitative Trait Loci

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  • Child and Adolescent Psychiatry
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The genetic complexity of autism spectrum disorders (ASD) can be addressed by studying correlated quantitative endophenotypes that have simpler modes of inheritance. Successful ASD endophenotypes will exhibit wide variation and substantial heritability. Quantitative trait loci (QTL) studies of these endophenotypes involve selecting an appropriate study sample that captures sufficient variation in those who are affected and possibly those who are unaffected. The choice of statistical algorithm for QTL mapping will depend on the individuals who can be studied and the distribution of the endophenotype. Although QTL studies for ASD are at an early stage, its application to ASD has led to initial successes.

Chapter.  11183 words.  Illustrated.

Subjects: Child and Adolescent Psychiatry ; Neurology ; Neuroscience

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