Chapter

Behavioral Evaluation of Genetic Mouse Models of Autism

Mu Yang, Maria Luisa Scattoni, Kathryn K. Chadman, Jill L. Silverman and Jacqueline N. Crawley

in Autism Spectrum Disorders

Published on behalf of Oxford University Press

Published in print May 2011 | ISBN: 9780195371826
Published online September 2012 | e-ISBN: 9780199965212 | DOI: http://dx.doi.org/10.1093/med/9780195371826.003.0058
Behavioral Evaluation of Genetic Mouse Models of Autism

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  • Child and Adolescent Psychiatry
  • Neurology
  • Neuroscience

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Autism is a complex neurodevelopmental disorder with extraordinarily high heritability. Intense efforts are now focusing on identifying genetic causes of autism. Animal models provide essential translational tools to investigate hypotheses about the biological causes of autism spectrum disorders, including candidate genes, synaptic and neuroanatomical abnormalities, environmental toxins, prenatal insults, and immune dysfunctions. Robust phenotypes in model organisms offer translational tools to identify causes and to seek putative treatments for autism. This chapter discusses the most promising mouse models of autism and strategies to phenotype new genetic lines of mice.

Chapter.  24725 words.  Illustrated.

Subjects: Child and Adolescent Psychiatry ; Neurology ; Neuroscience

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