Chapter

Linkage, Association, and Linkage Disequilibrium

Moyra Smith

in Phenotypic Variation

Published on behalf of Oxford University Press

Published in print February 2011 | ISBN: 9780195379631
Published online October 2012 | e-ISBN: 9780199975211 | DOI: http://dx.doi.org/10.1093/med/9780195379631.003.0004
Linkage, Association, and Linkage Disequilibrium

More Like This

Show all results sharing these subjects:

  • Clinical Genetics
  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

This chapter covers the identification of genes and allelic varients that are responsible for specific phenotypes, and range of genetic variation, variants and phenotypes. Also covered are GWAS and risk factors for type 2 diabetes, indications for shared causal variants in different diseases, limitations of GWAS, defining the key gene in a region linked to or associated with a specific phenotype, gene-environment interation (Herpes Simplex Virus and Alzheimer's Disease), HSV1 and mitochondrial sequences, genetic variation and drug response, large-scale multiethic studies on candidate genes, and the discover of disease genes though large-scales genomic sequencing.

Chapter.  4572 words.  Illustrated.

Subjects: Clinical Genetics ; Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.