Chapter

Neurodevelopment and Functional Genomics

Moyra Smith

in Phenotypic Variation

Published on behalf of Oxford University Press

Published in print February 2011 | ISBN: 9780195379631
Published online October 2012 | e-ISBN: 9780199975211 | DOI: http://dx.doi.org/10.1093/med/9780195379631.003.0008
Neurodevelopment and Functional Genomics

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  • Clinical Genetics
  • Clinical Cytogenetics and Molecular Genetics

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Key breakthroughs in analysis of neurophysiological processes include the capacity to analyze gene knockouts and gene mutants (most often in mice), and the ability to silence gene expression with short inhibitory ribonucleic acids (siRNAs) and to then observe the effects on the phenotype. Important insights have also been gained through neurophysiological studies, brain imaging and analyses of genes and their expression in patients with neurological and developmental defects.

Chapter.  7976 words.  Illustrated.

Subjects: Clinical Genetics ; Clinical Cytogenetics and Molecular Genetics

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