Chapter

Entorhinal Cortex

Edvard I. Moser, Menno P. Witter and May-Britt Moser

in Handbook of Brain Microcircuits

Published on behalf of Oxford University Press

Published in print August 2010 | ISBN: 9780195389883
Published online September 2012 | e-ISBN: 9780199965137 | DOI: http://dx.doi.org/10.1093/med/9780195389883.003.0017
Entorhinal Cortex

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  • Development of the Nervous System

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While decades of study have unraveled some of the basic principles of hippocampal structure and function, the adjacent entorhinal cortex has, in many respects, remained terra incognita. Recent studies suggest that the medial part of entorhinal cortex is part of a two-dimensional metric map of the animal's changing location in the environment. A key component of this map is the “grid” cell, which fires selectively at hexagonally spaced positions in the animal's environment. Grid cells co-localize with other recently discovered medial entorhinal cell types such as head-direction cells, conjunctive grid × head direction cells, and border cells. This chapter provides an overview of these functional cell types, their possible relationship to morphological cell types, the intrinsic architecture of the system, including laminar and longitudinal organization, and the extrinsic connectivity and possible function of both medial and lateral subdivisions of entorhinal cortex.

Chapter.  5679 words.  Illustrated.

Subjects: Development of the Nervous System

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