Evolution of Retinal Circuitry: From Then to Now

Frank S. Werblin and John Dowling

in Handbook of Brain Microcircuits

Published on behalf of Oxford University Press

Published in print August 2010 | ISBN: 9780195389883
Published online September 2012 | e-ISBN: 9780199965137 | DOI:
Evolution of Retinal Circuitry: From Then to Now

More Like This

Show all results sharing this subject:

  • Development of the Nervous System


Show Summary Details


The very early retinal studies, using primitive sharp electrode recording and staining tools, led to an initial description of layer-by-layer visual processing in the mudpuppy. Those studies uncovered the ON and OFF pathways, essential for differential information streams, originating at the bipolar cell level, and provide a circuit diagram showing excitatory connections between all major cell types. But that study missed entirely the multitude of inhibitory pathways mediated by diverse amacrine cells at the inner retina that provide functional richness to the many different ganglion cell types. The early simple description of retinal behavior is compared with the modern view of retinal circuitry. This chapter describes directionally selective ganglion cells as an example of functional circuit complexity.

Chapter.  3020 words.  Illustrated.

Subjects: Development of the Nervous System

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.