Locomotor Circuits in the Developing Rodent Spinal Cord

Kimberly Ole Kiehn and Dougherty J.

in Handbook of Brain Microcircuits

Published on behalf of Oxford University Press

Published in print August 2010 | ISBN: 9780195389883
Published online September 2012 | e-ISBN: 9780199965137 | DOI:
Locomotor Circuits in the Developing Rodent Spinal Cord

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Limbed locomotion in mammals involves complex activation of flexor and extensor muscles within a limb, and coordinated activity between the left and right legs. The phasing and timing of this complex motor act is to a large degree generated by neuronal circuitries or central pattern generators (CPGs) located in the spinal cord. The isolated spinal cord preparation from newborn rodents has become a model system for studying the neuronal basis underlying limbed locomotion in mammals. This chapter describes data from this model system that outline the basic organizational principles of the locomotor CPG, its development, and central control.

Chapter.  2865 words.  Illustrated.

Subjects: Development of the Nervous System

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