Chapter

HIV-1 and Tat Neuropathogenesis and Therapeutic Targets

Wenxue Li, Guanhan Li, Joseph Steiner and Avindra Nath

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI: http://dx.doi.org/10.1093/med/9780195399349.003.0019
HIV-1 and Tat Neuropathogenesis and Therapeutic Targets

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  • Disorders of the Nervous System
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The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the neuropathogenesis of HIV infection. This is the earliest protein to be produced by the proviral DNA in the infected cell. The protein not only drives the production and replication of the virus but is also actively released from the cell and then interacts with cell surface receptors of other uninfected cells in the brain leading to cellular dysfunction. It may also be taken up by these cells and can then activate a number of host genes. The Tat protein is highly potent and has the unique ability to travel along neuronal pathways. It can also easily cross the blood brain barrier. Importantly, its production is not impacted by the use of antiretroviral drugs once the proviral DNA has been formed. This chapter reviews the pleomorphic actions of Tat protein in relation to its effects on the nervous system.

Chapter.  15596 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

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