Chapter

HIV-1 and Meth

Howard S. Fox

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI: http://dx.doi.org/10.1093/med/9780195399349.003.0022
HIV-1 and Meth

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  • Disorders of the Nervous System
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The stimulant dextro (D)-Methamphetamine hydrochloride (methamphetamine, Meth) is a member of the amphetamine family of abused drugs. Meth is chemically related to amphetamine (dextroamphetamine), with the additional methyl group giving it enhanced lipophilicity, which increases its ability to cross the blood-brain barrier. Significant demographic overlap exists between those who use Meth and those at risk for HIV infection. Several research groups have studied the interaction of Meth and HIV in humans. HIV and Meth appear to have adverse, additive effects on frontal and striatal neuronal and glial markers; and rates of neurocognitive impairment appear to be higher in HIV-positive individuals who use Meth vs. those who do not. This chapter presents the result of clinical trials, non-human primate studies, and non-primate animal studies relevant to interactions between Meth use and HIV. The chapter also discusses Meth toxicity, the effects of Meth on central nervous system function, and interactions among aging, chronic HIV infection, and Meth use.

Chapter.  8128 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

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