CNS Comorbidities

Georgette D. Kanmogne and David B. Clifford

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI:
CNS Comorbidities

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  • Disorders of the Nervous System
  • Infectious Diseases


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This chapter gives a structured overview of the major HIV-related opportunistic and non-opportunistic infections of the CNS, including discussion of their interactions with immune reconstitution inflammatory syndrome (IRIS), stressing their pathogenesis, how they are affected by combination antiretroviral therapy, and the influence of geographic setting on prevalence, morbidity, and mortality. Part I discusses opportunistic infections (OIs). Considered are cytomegalovirus, cryptococcus, toxoplasmosis, and progressive multifocal leukoencephalopathy. Part II discusses IRIS and its interactions with specific OIs. Part III considers non-opportunistic infectious CNS complications, especially primary CNS lymphoma (closely associated with Epstein-Barr virus) and HIV encephalopathy.

Chapter.  18248 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

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