Chapter

Viral and Cellular Biomarkers During Antiretroviral Therapy

Scott L. Letendre and Ronald J. Ellis

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI: http://dx.doi.org/10.1093/med/9780195399349.003.0059
Viral and Cellular Biomarkers During Antiretroviral Therapy

More Like This

Show all results sharing these subjects:

  • Disorders of the Nervous System
  • Infectious Diseases

GO

Show Summary Details

Preview

The persistence of HIV-associated neurocognitive disorders (HAND) in patients who seem to be effectively treated with antiretroviral therapy is a subject of active investigation. This chapter examines the effects of antiretroviral therapy on viral and host biomarkers, drawing particular attention to data indicating that antiretroviral treatment may not be fully adequate with respect to the central nervous system. The chapter's focus is limited to biomarkers in cerebrospinal fluid, which is commonly used as a surrogate for pathologic and therapeutic events in the brain. In constructing this review, we performed a PubMed keyword search for “antiretroviral AND cerebrospinal fluid” and selected those publications that contained data relevant to the effects of antiretroviral therapy on a viral or host biomarker. Additional references were identified using marker-specific search terms such as “β2 microglobulin AND cerebrospinal fluid AND HIV.”

Chapter.  18262 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.