Chapter

Viral Clades

Wenxue Li and Avindra Nath

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI: http://dx.doi.org/10.1093/med/9780195399349.003.0061
Viral Clades

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  • Disorders of the Nervous System
  • Infectious Diseases

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Despite the rapid transglobal spread of HIV-1 infection, it has emerged as distinct subtypes or clades in different geographical regions. This sequence diversity seems to have profound effects in the spread of the virus, its ability to infect various cells types, the efficiency of viral replication, the propensity to develop drug resistance and their ability to cause neurocognitive disorders. While clade B virus is the still the best studied, it is becoming evident that clade D infected individuals have higher rates of neurocognitive disorders while the converse may be true for clade C infected individuals. This chapter reviews the evidence and the molecular basis for these clade differences.

Chapter.  3908 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

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