Chapter

Antiretroviral Nanotherapies

Madhavan P. N. Nair and Zainulabedin M. Saiyed

in The Neurology of AIDS

Third edition

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780195399349
Published online September 2012 | e-ISBN: 9780199965199 | DOI: http://dx.doi.org/10.1093/med/9780195399349.003.0071
Antiretroviral Nanotherapies

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  • Disorders of the Nervous System
  • Infectious Diseases

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Although highly active anti-retroviral therapy has significantly reduced the severity of HIV disease, complete eradication of virus from hard-to-access reservoirs in the HIV-infected patient remains a major challenge. The central nervous system, protected by its blood-brain barrier (BBB), represents one of the major anatomical reservoirs for HIV-1. Nanotechnology-based drug delivery systems have shown tremendous potential for penetrating the BBB and targeting antiretroviral drugs to the brain. This review highlights selected nanotechnology-based drug delivery systems that hold the potential for future effective treatment of HIV-associated neurocognitive disorders. Results from our laboratory on the use of magnetically-guided nanocarrier-based drug delivery systems for targeting active forms of antiretroviral drugs to the brain are discussed.

Chapter.  4439 words.  Illustrated.

Subjects: Disorders of the Nervous System ; Infectious Diseases

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