Chapter

Genetic epidemiology 2: molecular genetics

David Collier and Tao Li

in Practical Psychiatric Epidemiology

Published on behalf of Oxford University Press

Published in print August 2003 | ISBN: 9780198515517
Published online March 2013 | e-ISBN: 9780191754289 | DOI: http://dx.doi.org/10.1093/med/9780198515517.003.0018
Genetic epidemiology 2: molecular genetics

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The previous chapter has focused on methods for identifying familial clustering of disorders or traits, and on methods for distinguishing between shared genetic and environmental influences. The primary objective for this chapter is to outline techniques for identifying specific genes responsible for an observed phenotype. The theoretical basis of complex and quantitative traits was established many decades ago. However practical methods for the efficient molecular analysis of the human genome have only recently emerged. Alongside these developments, the molecular genetic analysis of human disorders has moved at a rapid pace. Molecular genetics has focused on single gene disorders with great success, whereas for complex psychiatric disorders, few genetic risk factors have been identified. However the tools used by the complex disorder geneticist have evolved rapidly in the last few years and better strategies and statistical methods continue to appear. This chapter outlines some established and novel approaches to the analysis of the genetics of complex human disorders. A basic understanding of genetical statistics will be useful.

Chapter.  7456 words.  Illustrated.

Subjects: Psychiatry ; Public Health and Epidemiology ; Epidemiology

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