α‎<sub>1</sub>-antitrypsin deficiency

R. Mark Beattie, Anil Dhawan and John W.L. Puntis

in Paediatric Gastroenterology, Hepatology and Nutrition

Published on behalf of Oxford University Press

Published in print March 2009 | ISBN: 9780198569862
Published online October 2011 | e-ISBN: 9780191725968 | DOI:

Series: Oxford Specialist Handbooks

α‎1-antitrypsin deficiency

More Like This

Show all results sharing these subjects:

  • Gastroenterology
  • Paediatrics


Show Summary Details


Clinical features 354

Management 355

Liver disease in other forms of α‎1-AT deficiency 355

α‎1-Antitrypsin (α‎1-AT) is a 55 kD glycoprotein produced predominantly by hepatocytes, alveolar macrophages and intestinal endothelial cells. It acts as a protease inhibitor during an acute-phase response. It can be electrophoretically differentiated into four main variants: PiM (normal), PiZ, PiS, and Pi Null (abnormal). There are >80 other rare, clinically irrelevant, variants. ...

Chapter.  626 words. 

Subjects: Gastroenterology ; Paediatrics

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.