Chapter

Pathogenesis

Dan J. Stein and Naomi A. Fineberg

in Obsessive-Compulsive Disorder

Published on behalf of Oxford University Press

ISBN: 9780199204601
Published online May 2011 | e-ISBN: 9780199606917 | DOI: http://dx.doi.org/10.1093/med/9780199204601.003.0003

Series: Oxf Psychiatry Library Series Paper

Pathogenesis

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• Cortico-striatal-thalamic-cortical (CSTC) neurocircuitry plays a key role in OCD • Serotonin (5-HT) and dopamine (DA) receptors in CSTC circuits appear particularly important • Particular variations in 5-HT and DA genes may contribute to vulnerability to OCD • Immune mechanisms may also play a role in contributing to CTSC dysfunction • OCD may involve a failure to inhibit evolutionarily-based procedural strategies • Both pharmacotherapy (SSRIs) and psychotherapy (CBT) can reverse CSTC dysfunction

Chapter.  5982 words.  Illustrated.

Subjects: Psychiatry

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