Chapter

Large-scale randomized evidence: trials and meta-analyses of trials

C. Baigent, R. Peto, R. Gray, S. Parish and R. Collins

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online November 2011 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.020303_update_002

Series: Oxford Textbooks

Large-scale randomized evidence: trials and meta-analyses of trials

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As long as doctors start with a healthy scepticism about the many apparently striking claims and counter-claims that appear in the medical literature, trial results do make sense. The main enemy of common sense is over-optimism: there are a few striking exceptions where treatments for serious disease work extremely well, but many claims of vast improvements from new therapies turn out to be evanescent....

Chapter.  11797 words.  Illustrated.

Subjects: Medical Statistics and Methodology

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