Neurosyphilis and neuro-AIDS

Hadi Manji

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

Neurosyphilis and neuro-AIDS

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Invasion of the central nervous system occurs early in the course of syphilis infection. Neurosyphilis causes meningitis, myeloradiculopathy due to pachymeningitis, and gummatous cord and brain lesions; endarteritis may cause infarction.

Clinical features—these are protean: neurosyphilis should always be considered in the diagnosis of neurological disorders without a convincing explanation, including (1) stroke—especially in young patients; (2) ocular abnormalities—e.g. optic neuritis, choroidoretinitis, pupillary abnormalities; (3) unexplained cranial nerve disease, including sensorineural deafness and vertigo; (4) dementia—low-grade meningo-encephalitis is associated with generalized changes in the brain and occasionally with frontotemporal dementia; (5) tabes dorsalis—a sensory ataxia caused by disease of the dorsal roots, ganglia and posterior columns....

Chapter.  6141 words.  Illustrated.

Subjects: Neurology

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