The nature and development of cancer

John R. Benson and Siong-Seng Liau

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

The nature and development of cancer

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Contemporary ideas of carcinogenesis envisage a series of random genetic changes that confer a selective growth advantage over healthy cells. These changes collectively lead to the disruption of coordinated networks of intercellular communication and cause a fundamental change in cellular behaviour which affects processes such as proliferation, differentiation, and apoptosis. This progressive dysregulation of cellular function implies that cancer is not a morphological entity, but a process in which the malignant phenotype is gradually acquired....

Chapter.  19231 words.  Illustrated.

Subjects: Medical Oncology

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