E.E. Ooi, L.R. Petersen and D.J. Gubler

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2012 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks


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  • Medical Microbiology and Virology
  • Infectious Diseases


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There are 29 registered alphaviruses belonging to the family Togaviridae, 16 of which are known to cause human infection. They are RNA viruses with global geographical distribution and complex transmission cycles between wild or domestic animals or birds and one or more mosquito species; humans are infected by mosquito bites. They cause a spectrum of clinical manifestations ranging from nonspecific febrile illness to acute encephalitis and death. Diagnosis of infection is made serologically by detection of IgM and IgG antibodies, virus isolation, and polymerase chain reaction, or by immunohistochemistry on tissue samples....

Chapter.  3923 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Infectious Diseases

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