Chapter

Flaviviruses excluding dengue

E.E. Ooi, L.R. Petersen and D.J. Gubler

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2012 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.070514_update_001

Series: Oxford Textbooks

Flaviviruses excluding dengue

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Flaviviruses, family Flaviviridae, are enveloped viruses with a single-strand positive-sense RNA genome approximately 11 kb in length. They comprise 53 species (40 of which can cause human infection), divided into three major groups based on epidemiology and phylogenetics. They are maintained in nature in complex transmission cycles involving a variety of animals and hematophagous arthropods, which transmit infection to humans. IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) is widely used for diagnosis, with confirmation requiring a four-fold or greater rise in specific antibodies between acute and convalescent serum samples, virus isolation, detection of specific antigen by immunohistochemistry or of viral RNA by nucleic acid amplification from blood or other tissue sample....

Chapter.  7387 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Infectious Diseases

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