Chapter

Viruses and cancer

R.A. Weiss

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2012 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.070526_update_001

Series: Oxford Textbooks

Viruses and cancer

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Viruses are important in cancer for three main reasons: (1) As a cause of cancer—about 15% of the worldwide cancer burden is due to viruses: retroviruses can activate cellular oncogenes; (2) In understanding of the biology of cancer—through the discovery and characterization of oncogenes and tumour-suppressor genes. (3) In the treatment of cancer—some viruses selectively replicate in and destroy proliferating cells, viruses as foreign antigens may aid the recognition of cancer cells by the host’s immune system (‘xenogenization’), and viruses can also be used as vectors for immunization and for gene therapy. Viral cancers are prevented by early screening for tumours, screening for the virus in order to prevent transmission, and immunization as in the cases of hepatitis B virus (HBV) and human papilloma virus (HPV)...

Chapter.  1679 words. 

Subjects: Medical Microbiology and Virology ; Infectious Diseases

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