Chapter

Intracellular klebsiella infections (donovanosis and rhinoscleroma)

J. Richens

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2012 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.070609_update_001

Series: Oxford Textbooks

Intracellular klebsiella infections (donovanosis and rhinoscleroma)

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Two rare intracellular species of Klebsiella, a Gram-negative bacillus, cause granulomatous disease in humans that is found in small endemic foci in warm climates, linked to poverty and poor hygiene.

Donovanosis—caused by Klebsiella granulomatis (until recently named Calymmatobacterium granulomatis); presumed to be sexually transmitted; presents with genital ulcers or growths, often accompanied by an inguinal ‘pseudobubo’ (granuloma inguinale). Diagnosed by demonstrating Donovan bodies (vacuoles containing capsulated coccoid bacteria) lying within histiocytes in material taken from a typical lesion. Treatment is with azithromycin; surgery may be needed for complications....

Chapter.  1873 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Infectious Diseases

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