Chapter

The pineal gland and melatonin

J. Arendt and T.M. Cox

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online November 2011 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.1313_update_001

Series: Oxford Textbooks

The pineal gland and melatonin

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The pineal gland transduces light–dark cycles into body rhythms by secretion of melatonin, an endogenous indoleamine derived from tryptophan, the concentrations of which in plasma and cerebrospinal fluid are up to 100 times higher at night than in the daytime. This exerts its effects through transmembrane, G-protein coupled receptors (MT1 and MT2) and nuclear receptors in the pituitary gland and hypothalamus....

Chapter.  2820 words. 

Subjects: Clinical Medicine

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