Chapter

Coeliac disease

Patrick C.A. Dubois and David A. van Heel

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online November 2012 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.151003_update_001

Series: Oxford Textbooks

Coeliac disease

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Case History—A 38 yr old woman presenting with a long history of tiredness and abdominal bloating.

Coeliac disease is a common disorder of the small intestine in which storage proteins in dietary wheat, rye, and barley (gliadin, secalins, hordeins, usually referred to as ‘gluten’) induce T-cell responses restricted by HLA DQ2 or DQ8. This immune response drives intestinal inflammation and loss of villous architecture and can lead to a wide spectrum of clinical manifestations....

Chapter.  5783 words.  Illustrated.

Subjects: Gastroenterology

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