Vascular and collagen disorders

Graham Neale

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

Vascular and collagen disorders

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A wide range of vascular and collagen disorders may affect the gastro-intestinal tract. Most are quite uncommon but presentations are often dramatic with intestinal bleeding or gangrene.

Vascular insufficiency leading to ischaemic damage of the gut may be caused by occlusion of mesenteric vessels by either arterial thrombosis (usually with atheromatous pathology); or venous thrombosis (in thrombophilic conditions); or arterial emboli (as occurs with atrial fibrillation); or diffuse small vessel occlusion. There are four primary syndromes. (1) Acute mesenteric ischaemia—typically manifest as the sudden onset of abdominal pain, initially without marked tenderness or localizing signs. Diagnosis requires a high index of suspicion and is often delayed. Imaging serves primarily to exclude other causes of an apparent abdominal catastrophe but prompt laparotomy for embolectomy and/or arterial re-construction and/or bowel resection is required to minimize damage to the gut. (2) Chronic mesenteric ischaemia—usually due to atheroma, presents with severe cramping abdominal pain 20 to 60 min, after eating. Diagnosis requires vascular imaging and usually the condition can be relieved only by revascularization. (3) Ischaemic colitis—presents with pain and tenderness in the left iliac fossa, nausea and vomiting, followed by the passage of a loose motion containing dark blood. Contrast enema examination characteristically shows ‘thumbprinting’ of the colonic mucosa. Most cases resolve spontaneously so supportive management is usually sufficient. (4) Ischaemia–reperfusion injury—diminishes the barrier function of the gut and may lead to septicaemia in those who are already critically ill....

Chapter.  4896 words.  Illustrated.

Subjects: Gastroenterology

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