Chapter

Allergic rhinitis

Stephen R. Durham and Hesham Saleh

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.1806

Series: Oxford Textbooks

Allergic rhinitis

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Allergic rhinitis affects more than 20% of the population of Westernized countries and has a significant impact on quality of life and school/work performance.

Aetiology and clinical features—important environmental factors include tree and grass pollens (seasonal allergic rhinitis); house dust mite and domestic pets, most often cats (perennial allergic rhinitis); and a variety of occupational exposures (occupational rhinitis). Many genetic loci confer susceptibility. Immediate symptoms (itching, sneezing, and watery nasal discharge) occur as a consequence of allergen cross-linking adjacent IgE molecules on the surface of mast cells in the nasal mucosa, resulting in the release of histamine and tryptase, and the generation of bradykinin....

Chapter.  4254 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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