The lung in vasculitis

A.U. Wells and Roland M. du Bois

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

The lung in vasculitis

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  • Respiratory Medicine and Pulmonology


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Case History—A 70 yr old man with a short history of severe breathlessness and widespread consolidation on his chest radiograph.

Case History—A 29 yr old woman with known asthma, now presenting with worsening respiratory and systemic symptoms.

Lung involvement in vasculitic disease can manifest in two ways: (1) Diffuse alveolar haemorrhage—presenting features include fever, weight loss, and other systemic symptoms in association with cough, breathlessness, and clinical signs suggestive of pneumonia. Haemoptysis may be present but is not invariable. A fall in haemoglobin over a day or longer is diagnostically useful. Bronchoalveolar lavage is usually diagnostic. (2) Other pulmonary vasculopathies—present with breathlessness on exertion. Investigation reveals isolated reduction in gas transfer (carbon monoxide diffusing capacity, D...

Chapter.  4537 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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