Chapter

Thin membrane nephropathy

Peter Topham and John Feehally

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2011 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.210802_update_001
Thin membrane nephropathy

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Thin membrane nephropathy is a common autosomal-dominant glomerular disorder that results in persistent microscopic haematuria and is pathologically characterized by the presence of diffuse and uniform thinning of the glomerular basement membrane. Recent genetic studies have identified mutations in the COL4A3 and COL4A4 genes in 40% of affected families. There is no specific treatment. Prognosis is excellent for most people, but a few cases with progressive renal impairment have been described.

Chapter.  1149 words.  Illustrated.

Subjects: Nephrology

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