Chapter

Haemolytic uraemic syndrome

Paul Warwicker and Timothy H J Goodship

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2011 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.211005_update_001

Series: Oxford Textbooks

Haemolytic uraemic syndrome

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The haemolytic uraemic syndrome (HUS) is characterized by the triad of: (1) microangiopathic haemolytic anaemia, (2) thrombocytopenia, and (3) acute renal failure. Endothelial cell activation leads to a change in phenotype from an anticoagulant to a procoagulant state.

Diarrhoeal associated (D+) HUS—this accounts for over 90% of cases and is the commonest cause of acute renal failure in children. The usual pathogen is enterohaemorrhagic ...

Chapter.  3543 words. 

Subjects: Nephrology

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