Malignancy-associated renal disease

A Neil Turner

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2011 | e-ISBN: 9780199570973 | DOI:
Malignancy-associated renal disease

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Malignancies can affect the kidneys by direct invasion, metabolic and remote effects of tumour products, deposition of tumour products, triggering of immune reactions, and effects of treatment.

Particular malignancy-associated renal diseases include:

1 Thrombotic microangiopathy—particularly reported for malignancies of the stomach, pancreas, and prostate, and also with certain chemotherapeutic agents.

2 Minimal-change nephrotic syndrome—rarely caused by lymphoma.

3 Membranous nephropathy—associated with malignancy, usually of solid organs, in 5 to 11% of cases. Malignant disease is typically advanced and obvious when nephrotic syndrome or heavy proteinuria is recognized. Very few treatable and otherwise subclinical tumours are uncovered by investigation in routine clinical practice.

4 Focal necrotizing and crescentic nephritis—may rarely be associated with malignancy when they are usually antineutrophil cytoplasmic antibody (ANCA) negative.

5 Proteinuria—may be caused by agents that modulate interferons or vascular endothelial growth factors.

Chapter.  2013 words. 

Subjects: Nephrology

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