Chapter

Acute lymphoblastic leukaemia

Tim Eden

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.220303

Series: Oxford Textbooks

Acute lymphoblastic leukaemia

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Genetic changes in key progenitor cells in acute lymphoblastic leukaemia (ALL) are typically either point mutations or (more frequently) translocation of proto-oncogenes to active promoter sites, with such genetic rearrangements leading to aberrant protein production. In most childhood disease the first genetic events arise in utero...

Chapter.  4421 words. 

Subjects: Haematology

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