Acute myeloid leukaemia

Jonathan Kell, Steve Knapper and Alan Burnett

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

Acute myeloid leukaemia

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It is believed that acute myeloblastic leukaemia arises in a haematopoietic stem cell as a result of mutations which promote growth or inhibit apoptosis arising in association with mutations that inhibit differentiation. In most cases there is no obvious cause, but exposure to chemical and ionizing radiation may be relevant, including previous chemotherapy for solid tumours....

Chapter.  5629 words.  Illustrated.

Subjects: Haematology

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