Chapter

Myelodysplasia

Lawrence B. Gardner and Chi V. Dang

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.220307

Series: Oxford Textbooks

Myelodysplasia

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Myelodysplasia is a common haematological disorder that may occur at any age, although prevalence increases with age and most patients are over 60 years old. It is associated with a wide variety of acquired clonal abnormalities that may affect all lineages of blood cells and frequently lead to the development of leukaemia. Some particular chromosomal abnormalities are characteristic, and in a few cases functional studies of candidate genes implicated in the chromosomal abnormalities suggest cause–effect relationships, e.g. an activating mutation in the JAK2 kinase....

Chapter.  5817 words.  Illustrated.

Subjects: Haematology

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