Chapter

Paroxysmal nocturnal haemoglobinuria

Lucio Luzzatto

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI: http://dx.doi.org/10.1093/med/9780199204854.003.220312

Series: Oxford Textbooks

Paroxysmal nocturnal haemoglobinuria

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Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder in which a substantial proportion of the patient’s red cells have an abnormal susceptibility to activated complement. This results from the presence of a clone that originates from a haematopoietic stem cell bearing an acquired somatic mutation in the X-linked gene ...

Chapter.  3156 words.  Illustrated.

Subjects: Haematology

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