James O. Armitage

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online November 2012 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks


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Lymphomas are malignancies of lymphoid cells. Genetic abnormalities determine the nature of a lymphoma by leading to the overexpression, underexpression, or abnormal expression of specific genes (‘oncogenes’), which are typically those that regulate cell cycle differentiation, rate of proliferation, and apoptosis.

Clinical features—the usual manifestation is with palpable nontender lymphadenopathy. Symptoms from a large mediastinal mass are a common initial presentation. A significant minority of patients present with fevers, night sweats and/or weight loss. Manifestations due to bone marrow or gastrointestinal tract involvement are seen frequently in some subtypes of disease....

Chapter.  14866 words.  Illustrated.

Subjects: Haematology

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