Vesiculobullous disease

Fenella Wojnarowska

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online May 2010 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

Vesiculobullous disease

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The autoimmune blistering diseases have a dramatic clinical presentation, and are significant diseases with substantial morbidity and mortality.

The diseases can be split broadly pathologically into intraepidermal (pemphigus) and subepidermal (pemphigoid, dermatitis herpetiformis and others) groups, the former being characterized by pathogenic autoantibodies to desmosome components, and the latter by pathogenic antibodies to proteins of the basement membrane zone adhesion complex that link the epithelium/epidermis to the underlying mesenchyme/dermis (or genetic mutations of the same proteins). There are concomitant differences in clinical presentation, e.g. blistering lesions present in the subepidermal bullous diseases tend to be less easily ruptured than those observed in intraepidermal bullous diseases....

Chapter.  4062 words.  Illustrated.

Subjects: Dermatology

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